ea0021p329 | Steroids | SFEBES2009
Halsall David
, Owen Laura
, Viljoen Adam
, Taylor Kevin
, Simpson Helen
, Chatterjee Krishna
, Gurnell Mark
Metyrapone (MT) is used in the medical management of Cushings syndrome as it decreases serum cortisol (CT) levels by inhibiting adrenal β-hydroxylation of 11-deoxycortisol, the final step in CT synthesis. CT precursors, in particular 11-deoxycortisol (DOC), increase following MT therapy. Monitoring glucocorticoid replacement in patients taking MT could therefore be confounded as DOC cross-reacts in commonly used immunoassays (IA) for serum CT. Serum CT results from ...